Anti-CYP1A1 Antibody

CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a phase I xenobiotic-metabolizing enzyme that oxidizes polycyclic aromatic hydrocarbons, arylamines, and several clinically used drugs. The rabbit polyclonal antibody from Antibodies.com detects endogenous CYP1A1 in human, mouse, and rat samples using Western blot and immunohistochemistry workflows. It is supplied as 100 µl of unconjugated antiserum in a vial, supporting research into xenobiotic metabolism, aryl hydrocarbon receptor signaling after dioxin-like ligand exposure, and tobacco-smoke carcinogen bioactivation. Store at -20 degrees C in working aliquots to limit freeze-thaw cycles and avoid repeated freeze-thaw of the stock vial. The polyclonal format provides multi-epitope recognition, which is helpful when probing CYP1A1 across tissues such as liver, lung, and intestine where expression varies with inducer status. For Western blot, the antibody recognizes the approximately 55 kDa CYP1A1 protein; for immunohistochemistry, antigen retrieval conditions should be optimized for the specific fixation protocol.