Anti-CYP17A1 Antibody

Antibodies.com offers this rabbit polyclonal antibody directed against CYP17A1 (cytochrome P450 family 17 subfamily A member 1), the steroidogenic enzyme that catalyzes both 17α-hydroxylase and 17,20-lyase activities central to cortisol and androgen biosynthesis. Raised in rabbit and supplied as an unconjugated reagent at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the antibody is provided in a 100 µL vial and validated in Western blot and immunohistochemistry on human samples, supporting studies of adrenal and gonadal steroidogenesis.

The target, a microsomal approximately 57 kDa enzyme expressed in the adrenal cortex, testicular Leydig cells, and ovarian theca cells, is clinically linked to 17α-hydroxylase deficiency and forms a major research focus in prostate cancer hormone-pathway investigations where inhibitors such as abiraterone act on its 17,20-lyase function.

Storage recommendations call for keeping the vial refrigerated short term and freezing at –20 °C long term, with aliquoting advised to limit freeze-thaw cycles and preserve immunoreactivity for downstream assay work such as Western blot band detection around the expected 57 kDa region.