Anti-CYP11B2 Antibody

Aldosterone synthase, the mitochondrial cytochrome P450 enzyme encoded by CYP11B2, catalyzes the terminal hydroxylations that convert 11-deoxycorticosterone into aldosterone in the zona glomerulosa of the adrenal cortex. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is raised against CYP11B2 and validated for Western blot detection of the protein in human and mouse samples. The product is supplied at approximately 1 mg/ml in phosphate buffered saline (PBS), pH 7.2, with 15 mM sodium azide as preservative, in a 50 µl vial aliquot prepared for routine immunoblotting applications. Investigators working on primary aldosteronism, secondary hypertension, RAAS dysregulation, adrenal cortical biology, and cardiovascular remodeling use this antibody to profile endogenous CYP11B2 expression. Polyclonal sera cover a broader epitope spread than monoclonal alternatives, which is valuable when probing minor sequence variants or partially denatured lysate preparations. Frozen aliquots should be thawed on ice and stored refrigerated at 4 degrees C for short-term handling, with longer term storage at -20 degrees C to preserve activity across repeated Western blot experiments.