Anti-CYP11B1 Antibody

Mitochondrial cytochrome P450 11B1 catalyzes the 11β-hydroxylation step in glucocorticoid biosynthesis, converting 11-deoxycortisol to cortisol and 11-deoxycorticosterone to corticosterone within the zona fasciculata of the adrenal cortex. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com was raised against CYP11B1 and is validated for Western blot detection of the endogenous enzyme in human and mouse samples. It is supplied in a 50 µl vial and is intended for research use only.

The reagent is commonly used in studies of steroid metabolism, adrenal cortex zonation, and the molecular basis of 11β-hydroxylase deficiency, a form of congenital adrenal hyperplasia linked to hypertension, salt imbalance, and excess androgen production. Researchers working on hypothalamic–pituitary–adrenal axis signaling, glucocorticoid feedback regulation, or adrenal tumor biology also use this antibody to probe CYP11B1 expression levels in cell lysates and tissue homogenates. The polyclonal host format provides epitope diversity useful for recognizing full-length endogenous protein, and the unconjugated IgG format allows secondary antibody flexibility for chromogenic or chemiluminescent Western blot workflows in endocrinology and steroidogenesis research.