Anti-CYCS Antibody

The CYCS target encodes cytochrome c, somatic, a roughly 12 kDa heme protein residing in the mitochondrial intermembrane space where it shuttles electrons between Complex III and Complex IV during oxidative phosphorylation. This polyclonal reagent from Antibodies.com was raised in rabbit and is supplied as 100 µL of unconjugated antiserum validated for Western blot and immunohistochemistry workflows. In apoptosis research, cytochrome c release into the cytosol is a hallmark of intrinsic pathway activation, making reliable CYCS detection central to studies of mitochondrial outer membrane permeabilization.

The antibody reacts with human, mouse, and rat samples, supporting comparative work in cell line panels and rodent tissue models. Researchers commonly resolve the target as an approximately 12 kDa band by SDS-PAGE and Western blot, and apply it to fixed paraffin-embedded sections for IHC localization in tissues such as brain, liver, and heart. Aliquot upon arrival and store refrigerated; protect from light to preserve antibody activity. For research use only.