Anti-Cyclooxygenase 2 Antibody

Cyclooxygenase 2 (COX-2), also known as prostaglandin-endoperoxide synthase 2 (PTGS2), is the inducible isoform of the COX enzyme family and drives prostaglandin production during inflammation, pain signaling, and tumor-promoting microenvironments. Researchers studying acute and chronic inflammatory disease, colorectal and breast cancer biology, and NSAID pharmacology use anti-COX-2 antibodies to map where the enzyme is expressed in tissues and how its levels shift in response to stimuli such as cytokines, growth factors, and lipopolysaccharide.

This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied as 100 µl of antibody raised against Cyclooxygenase 2 and validated for Western blot and immunohistochemistry on human samples. The unconjugated format lets laboratories pair it with their preferred HRP, biotin, or fluorophore secondary detection systems, and the polyclonal nature provides broader epitope coverage for detecting the full-length COX-2 protein and its common splice variants and post-translationally modified forms in lysates and tissue sections.

Recommended storage is at -20 °C in working aliquots to limit freeze-thaw cycles, with brief 4 °C storage acceptable for short-term use. The antibody is intended for research use only and is suited to studies of prostaglandin biosynthesis, inflammatory signaling pathways, tumor angiogenesis, and biomarker discovery in formalin-fixed paraffin-embedded tissue sections and Western blot workflows.