Anti-Cyclin E1 Antibody

Produced in rabbit as a polyclonal reagent, this unconjugated primary antibody recognizes Cyclin E1, a key regulator of the G1/S phase transition in the cell cycle. Cyclin E1 partners with CDK2 to drive Rb phosphorylation and S-phase entry, and its dysregulation is widely studied in oncology, where overexpression has been linked to aggressive tumors and altered proliferation.

Researchers apply this reagent across Western blot analysis of cyclin E1 expression, immunohistochemistry for tissue distribution studies, immunofluorescence imaging of subcellular localization, and ELISA-based quantification. Supplied as 100 µl of unconjugated antibody, the format supports flexible pairing with HRP, fluorescent, or biotinylated secondaries.

Cross-reactivity with mouse, rat, and human samples enables comparative work across common model organisms. Each lot is validated at Antibodies.com for the indicated applications, supporting reproducible detection in cell lysate and tissue-based protocols.