Anti-Cyclin A1 Antibody

This rabbit polyclonal primary antibody from Antibodies.com targets Cyclin A1 (CCNA1), a meiosis-associated cyclin that regulates CDK activity during the G1/S and G2/M phases of the cell cycle. Unlike the more broadly expressed Cyclin A2, Cyclin A1 is predominantly found in spermatocytes and is also reactivated in certain hematological malignancies and solid tumors, making it a relevant marker for reproductive biology research and oncology studies.

The antibody is supplied in a 100 µl vial as an unconjugated, polyclonal reagent raised in rabbit, with reactivity confirmed against human Cyclin A1. It is validated for Western blot (WB) and immunohistochemistry (IHC) workflows, supporting detection of endogenous protein levels in cell lysates and tissue sections.

Cyclin A1 functions by binding and activating cyclin-dependent kinases CDK2 and CDK1, driving cell cycle progression. Its restricted expression pattern in normal tissues, combined with ectopic expression in leukemias such as acute myeloid leukemia, positions this reagent for studies of germ cell development, spermatogenesis, and tumor biology. Researchers investigating DNA replication, mitotic entry, or meiotic regulation can apply this antibody in their experimental designs.