Anti-CXXC1 Antibody

From Antibodies.com, this rabbit polyclonal reagent targets the chromatin-associated protein CXXC1, a CXXC-type zinc finger that anchors the SET1/COMPASS H3K4 methyltransferase complex to unmethylated CpG islands across the genome. The unconjugated antibody is supplied as 100 µl per vial, intended for chromatin immunoprecipitation (ChIP), western blot, immunohistochemistry, and immunofluorescence workflows.

CXXC1, also known as CFP1 or CGBP, reads CpG methylation status and recruits chromatin-modifying activity that regulates transcription of CpG island-associated genes, including pluripotency factors in embryonic stem cells. Investigators studying epigenetic gene regulation, X-inactivation, hematopoiesis, or the DNA methylation landscape apply this antibody to map CXXC1 chromatin occupancy by ChIP, confirm expression in tissue sections by IHC, or localize the protein in fixed cells by immunofluorescence. The reagent has been validated for reactivity with human, mouse, and rat samples.

As a polyclonal antibody raised in rabbit, the reagent recognizes multiple epitopes on CXXC1, supporting robust detection under denaturing western blot conditions and in fixed tissue or cell preparations. Aliquot on receipt and protect from light to preserve immunoreactivity across repeated freeze-thaw cycles. For research use only.