Anti-CXXC1 Antibody

CXXC1, also known as CGBP or CFP1, is a zinc finger CpG-binding protein that anchors the SET1/COMPASS histone H3 lysine 4 methyltransferase complex to unmethylated CpG islands across the genome. This rabbit polyclonal antibody from Antibodies.com is raised against CXXC1 and validated for western blot, immunohistochemistry, immunofluorescence, and chromatin immunoprecipitation workflows, supporting research into epigenetic regulation, histone methylation, and CpG island biology.

Reactivity with human, mouse, and rat CXXC1 enables comparative studies across common model systems. The unconjugated format offers flexibility for pairing with secondary antibodies, fluorophores, or beads, while the polyclonal antibody recognizes multiple epitopes, a useful feature for chromatin immunoprecipitation, where cross-linking and epitope accessibility can vary at CpG-rich promoters.

The product is supplied as 100 µl of liquid at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol. Sodium azide acts as a preservative for short-term use, while the glycerol allows the antibody to be stored frozen between uses. Aliquoting is recommended to limit freeze-thaw cycles and preserve binding activity over the lifetime of the vial.