Anti-CXCR6 Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com targets the CXCR6 chemokine receptor, a seven-transmembrane G protein-coupled receptor also known as BONZO or STRL33 that mediates lymphocyte trafficking in response to the transmembrane chemokine CXCL16. Raised in rabbits and affinity-purified for research use, the antibody recognizes both human and mouse CXCR6, supporting studies of immune cell migration, inflammatory tissue infiltration, and tumor microenvironment biology in hepatocellular carcinoma, colorectal cancer, and other CXCL16-expressing tissues.

Each vial contains 100 µl of polyclonal antiserum supplied at a working concentration suitable for standard western blot and immunohistochemistry workflows. Researchers can apply the reagent to formalin-fixed paraffin-embedded sections for IHC detection of CXCR6-positive infiltrating lymphocytes, or to whole-cell lysates and membrane preparations for western blot analysis of receptor expression across immune and epithelial populations. The unconjugated format allows users to pair the antibody with HRP, biotin, or fluorophore-conjugated secondary reagents of their choice, and to optimize detection conditions for individual sample types, including frozen sections, fresh isolates, and fixed archival material.

Because CXCR6 expression marks specific subsets of tissue-resident memory T cells, NKT cells, and NK cells, this polyclonal reagent is useful for characterizing inflammatory infiltrates in liver, gut, and tumor tissues, and for exploring the receptor's role in viral entry and chronic inflammation. Storage and handling should follow standard antibody protocols; refer to the accompanying data sheet for recommended dilutions, blocking conditions, and species-specific validation data for human and mouse samples.