Anti-Cullin 2 Antibody

The CRL2 (Cullin-RING Ligase 2) ubiquitin ligase complex, in which Cullin 2 acts as the central scaffold, can be detected at endogenous levels with this unconjugated rabbit polyclonal IgG reagent supplied at 100 µl by Antibodies.com. Validated for western blot, immunohistochemistry, and immunofluorescence on human samples, the antibody recognizes multiple epitopes on the Cullin 2 target, helping produce specific bands and staining across varied cell lysates and fixed tissue sections. Cullin 2 nucleates substrate recruitment within cullin-RING ligases that mediate ubiquitin-dependent proteolysis, with established connections to oxygen sensing through the pVHL axis, cell-cycle progression, and the DNA damage response, making the reagent useful for studies on hypoxia signaling pathways, tumor biology, and proteasome-mediated protein turnover. The polyclonal format also gives users flexibility to deploy it as a primary detection reagent in custom assay setups or as a labeling target for immunofluorescence imaging workflows.