Anti-CUL5 Antibody

Targeting the cullin-5 scaffold protein that anchors CRL5 E3 ubiquitin ligase complexes, this rabbit polyclonal reagent from Antibodies.com is supplied as 100 µl of unconjugated antiserum validated for western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples. CUL5 forms the organizing backbone of multi-substrate RING ligases that pair with Elongin B, Elongin C, and SOCS-box adaptors to direct proteasomal turnover of regulatory substrates, a pathway famously co-opted by HIV-1 Vif to defeat host APOBEC3G restriction. Investigators working on hepatocellular carcinoma, viral immune evasion, cytokine-JAK-STAT signaling, and cell cycle checkpoint control rely on anti-CUL5 antibodies to profile endogenous expression in cultured cell lines, primary tissues, and formalin-fixed paraffin-embedded sections. The polyclonal format provides multi-epitope recognition of the ~90 kDa target, supporting consistent band detection on western blots and clear cytoplasmic staining in IHC and IF preparations. Aliquot upon receipt and store refrigerated to limit freeze-thaw cycles and preserve antibody activity for downstream applications.