Anti-CUL5 Antibody

CUL5 (Cullin 5) is a scaffold protein that assembles Cullin-RING E3 ubiquitin ligase complexes, driving ubiquitination and proteasomal turnover of substrate proteins in human, mouse, and rat cells. This unconjugated rabbit polyclonal reagent from Antibodies.com targets CUL5 for detection in western blot, immunohistochemistry, and immunofluorescence workflows. The antibody is supplied at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial suitable for repeated use across multiple experiments. CUL5 participates in diverse cellular pathways, including cell-cycle progression, signal transduction, and innate immunity, and is well known for its role as a host factor recruited by HIV-1 Vif to degrade the antiviral cytidine deaminase APOBEC3G. Researchers investigating ubiquitination biology, viral-host interactions, or the broader cullin family will find this reagent a versatile tool for confirming expression, mapping subcellular localization, and validating functional studies. Recommended storage at -20 °C preserves antibody activity for long-term projects.