Anti-CUL4B Antibody

Cullin 4B (CUL4B) forms the scaffold subunit of the CRL4 E3 ubiquitin ligase complex, a multifunctional assembly that regulates chromatin remodeling, cell cycle progression, and the nucleotide excision repair pathway. Loss-of-function mutations in CUL4B are linked to X-linked intellectual disability, and the protein is widely studied in the context of UV-induced DNA damage, nucleotide excision repair, and replication stress. Antibodies.com provides a rabbit polyclonal anti-CUL4B reagent raised against this target.

The unconjugated antibody is supplied at 100 µL per vial and has been validated in Western blot and immunofluorescence applications against human, mouse, and rat samples. Researchers use it to monitor CRL4-mediated ubiquitination of DDB1-associated substrates, to profile CUL4B expression across cell lines and tissue sections, and to follow changes in protein abundance following genotoxic insult. Aliquot upon arrival and store refrigerated to preserve activity across repeated freeze-thaw cycles; the reagent is intended for research use only.