Anti-CUL4B Antibody

This rabbit polyclonal antibody targets CUL4B, a scaffold component of the CRL4 E3 ubiquitin ligase complex that regulates DNA damage repair, cell cycle progression, and chromatin remodeling through substrate ubiquitination. Provided at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

CUL4B (Cullin 4B) is an X-linked gene whose loss-of-function mutations are linked to syndromic intellectual disability, and its overexpression has been documented in several cancer types, making it a focus of ongoing neurodevelopmental and oncology research. The polyclonal format provides recognition of multiple epitopes on CUL4B, supporting reliable detection in tissue sections and cell preparations.

Each vial contains 100 µl of antibody from Antibodies.com, ready to use at recommended starting dilutions for your specific application. Store the product at 4°C for short-term use or aliquot and freeze at -20°C for longer-term storage to preserve antibody activity.