Anti-CUL4B Antibody

The Cullin 4B (CUL4B) scaffold protein anchors the CRL4 E3 ubiquitin ligase complex, guiding substrate selection for ubiquitin-mediated proteolysis and supporting chromatin remodeling, nucleotide excision repair, and the DNA damage response. Loss-of-function mutations in CUL4B cause X-linked intellectual disability (Cabezas syndrome), while overexpression has been reported in colorectal, hepatocellular, and other carcinomas, so researchers profile this target across neurodevelopmental, DNA repair, and oncology studies.

This rabbit polyclonal IgG reagent is supplied by Antibodies.com as a 50 µl vial in unconjugated format and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows. Reactivity with Human, Mouse, and Rat samples enables parallel interrogation of patient-derived cell lines, archived primary tissue, and rodent model specimens. The polyclonal format recognizes multiple epitopes, which is useful when probing post-translationally modified CUL4B or alternatively spliced isoforms that monoclonal reagents may miss.

For research use only; refrigerate upon arrival and aliquot to limit freeze-thaw cycles.