Anti-CUL4A Antibody

CUL4A (Cullin 4A) functions as a scaffold component of the CRL4 E3 ubiquitin ligase complex, and this primary antibody reagent from Antibodies.com enables detection of the protein in western blot and immunohistochemistry workflows. Raised in rabbit as a polyclonal antiserum, the unconjugated antibody is supplied as 100 µl and has been validated for reactivity with human, mouse, and rat samples, supporting translational research where cross-species comparison is needed.

CUL4A assembles with DDB1 and DCAF substrate receptors to ubiquitinate targets involved in DNA damage response, cell cycle checkpoint control, and nucleotide excision repair, so this reagent is commonly used in studies of CRL4-dependent proteostasis, p21/p27 turnover, and tumor biology. The polyclonal format offers recognition of multiple epitopes on the cullin scaffold, which can be advantageous when working with formalin-fixed paraffin-embedded tissue for IHC or with samples where post-translational modifications may mask a single antigenic site. Researchers investigating genomic stability, DNA repair pathways, and oncogenic signaling will find this antibody applicable for confirming expression of the endogenous cullin and for probing alterations in CRL4 complex assembly.