Anti-CUL4A Antibody

This rabbit polyclonal antibody from Antibodies.com targets Cullin 4A (CUL4A), an evolutionarily conserved scaffold protein that forms the catalytic core of CRL4 E3 ubiquitin ligase complexes. By recruiting DDB1 and substrate receptors such as DCAFs, CUL4A drives ubiquitin-dependent turnover of key regulators of DNA replication, nucleotide excision repair, and the G1/S checkpoint, making the protein a frequent subject in studies of genome stability, DNA damage response, and tumor biology. The reagent is supplied as an unconjugated IgG in a 200 µl vial and is validated for western blot detection of endogenous CUL4A in human and mouse samples, enabling comparative work between both species. It is raised in rabbit and fits standard immunoblotting workflows that employ HRP- or fluorophore-conjugated secondary reagents. Aliquot on receipt and store at -20°C, minimizing freeze-thaw cycles to preserve binding activity; each vial supports multiple western blots once titred to the optimal working dilution.