Anti-CUL3 Antibody

Cullin-3 (CUL3) is a scaffold protein central to the assembly of Cullin-RING E3 ubiquitin ligase complexes, which tag selected substrates with ubiquitin chains for proteasomal turnover. Antibodies.com offers a rabbit polyclonal antibody raised against CUL3 that supports Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat sample types. The unconjugated reagent is supplied as 100 µl of polyclonal serum, allowing flexible labelling and secondary antibody pairing for individual laboratory assays. CUL3 immunostaining is commonly used to investigate substrate adaptor biology, including roles in NRF2 oxidative-stress regulation, mitotic checkpoint control, and ion channel trafficking, giving researchers a tractable readout for E3 ligase function in cell biology and pathology studies. For short-term use, aliquot and store refrigerated at 4 °C; for longer retention, keep frozen at -20 °C in single-use portions to limit freeze-thaw cycles and preserve antigen-binding activity.