Anti-CUL-3 Antibody

This rabbit polyclonal antibody from Antibodies.com is raised against Cullin-3 (CUL-3), a scaffold component of the Cullin-RING E3 ubiquitin ligase complex. CUL-3 assembles with RING finger protein RBX1 and BTB domain-containing substrate adaptors to mediate polyubiquitination of cellular substrates, marking them for proteasomal degradation. This ligase activity contributes to regulation of multiple cellular pathways, including oxidative stress responses and autophagy. The antibody is validated for Western blot and immunofluorescence on human samples and is supplied as an unconjugated reagent in a 100 µl vial, intended for research use only.