Anti-CUL-3 Antibody

CUL-3 (Cullin-3) is a scaffold component of the Cullin-RING E3 ubiquitin ligase complex, mediating protein ubiquitination and degradation through the proteasome pathway. This rabbit polyclonal antibody from Antibodies.com detects endogenous levels of CUL-3 in human and mouse samples, validated for Western blot, immunohistochemistry, and ELISA applications. The unconjugated IgG is supplied as 100 µl of ready-to-use reagent, suitable for researchers investigating ubiquitin-proteasome signaling, cell cycle regulation, and DNA damage response pathways. CUL-3 functions in substrate recognition through its association with BTB domain adaptor proteins, and dysregulation is implicated in pseudohypoaldosteronism type II and certain cancers. The polyclonal format provides recognition of multiple epitopes, supporting robust detection across varied sample preparations including cell lysates, tissue sections, and recombinant protein.