Anti-CUL-2 Antibody

Raised in rabbit against the Cullin-2 scaffold protein, this unconjugated polyclonal antibody from Antibodies.com targets a central component of the CRL2 family of Cullin-RING E3 ubiquitin ligases. CUL-2 organizes substrate recognition modules through its elongated architecture, binding elongin B and elongin C at its C-terminal region to assemble complexes that include the VHL tumor suppressor and various BC-box substrate adapters. Through those complexes the protein directs ubiquitin-dependent turnover of substrates involved in hypoxia sensing, cell cycle progression, and DNA damage signaling, making reliable detection tools for CUL-2 valuable in studies of proteostasis and tumor biology.

Supplied as 100 µl of affinity-purified antiserum, the reagent is validated for Western blot, immunohistochemistry, immunofluorescence, and ELISA workflows on human and mouse samples. The unconjugated format allows researchers to pair the antibody with HRP, fluorophore, or biotin detection chemistries of their own choice, and the polyclonal response supports recognition of multiple epitopes on the target protein for broader detection in denatured and native preparations. Storage at 2-8 degrees C in the supplied vial preserves activity for routine bench use, with aliquots recommended to limit freeze-thaw cycles.