Anti-CTSH Antibody

CTSH encodes cathepsin H, a lysosomal cysteine protease of the papain family that contributes to intracellular protein turnover, antigen processing in immune cells, tumor cell invasion in several cancers, and amyloid-beta clearance studied in Alzheimer's pathology. The rabbit polyclonal reagent from Antibodies.com is raised against this target and supplied as an unconjugated IgG preparation at 100 µl per vial, sufficient for routine blotting and staining workflows. The antibody detects the human protein and shows reactivity with mouse and rat orthologs, supporting cross-species translational studies on tissue lysates and fixed sections.

Validated applications include Western blot, where it labels the ~28 kDa mature chain and the ~41 kDa proform from cell and tissue lysates, and immunohistochemistry on formalin-fixed paraffin-embedded sections, producing granular cytoplasmic staining consistent with lysosomal localization. The polyclonal format samples multiple epitopes, tolerating minor denaturation and remaining useful when probing processed fragments of the zymogen. For reliable performance, store refrigerated in working aliquots to limit freeze-thaw exposure and protect from light until use.