Anti-CTSD Antibody

Cathepsin D is a lysosomal aspartic protease that plays central roles in intracellular protein turnover, apoptosis regulation, and tumor cell invasion. Antibodies.com provides a rabbit polyclonal anti-CTSD reagent of 100 µL volume, unconjugated, validated for Western blot and immunohistochemistry workflows on human, mouse, and rat samples.

Widely expressed across epithelial and neural tissues, cathepsin D functions as a key hydrolytic enzyme within acidic endosomal and lysosomal compartments. Researchers can use this reagent to monitor CTSD expression in cell lysates by Western blot, where the enzyme is detected as a pro-form that undergoes proteolytic maturation into heavy and light chain subunits. For immunohistochemistry, the antibody supports localization studies in formalin-fixed, paraffin-embedded tissue sections, allowing investigators to map protease distribution in normal versus diseased specimens.

The reagent fits research programs in cancer biology, neurodegeneration, and lysosomal storage disorders, where altered cathepsin D activity or processing has been linked to disease progression. Polyclonal reactivity against multiple epitopes on CTSD increases the likelihood of recognizing both pro-enzyme and mature forms across sample types. The unconjugated format allows users to pair the antibody with their preferred secondary detection system, whether chromogenic, fluorescent, or chemiluminescent.