Anti-CTNNB1 (phospho S37) Antibody

Beta-catenin phosphorylation at serine 37 is a central regulatory event within the canonical Wnt signaling cascade. This phospho-specific reagent from Antibodies.com enables researchers to detect the GSK-3β-primed, degradation-targeted form of CTNNB1 in western blot and immunohistochemistry workflows.

Raised in rabbit as a polyclonal IgG, the antibody is supplied unconjugated at 50 µl per vial, supporting both endpoint and titration-based assay design. Cross-reactivity has been characterized for human, mouse, and rat samples, making it suited to comparative oncology studies, stem-cell differentiation models, and developmental biology investigations where Wnt-driven β-catenin turnover is a key experimental readout.

Researchers commonly use phospho-S37 detection to monitor pathway activation status, validate upstream GSK-3β kinase activity, or characterize tumor specimens carrying CTNNB1 mutations within the N-terminal phosphodegron motif. The unconjugated format also allows flexible secondary antibody pairing and downstream signal amplification strategies tailored to specific sample types and imaging platforms.