Anti-CTNNB1 Antibody

Beta-catenin (CTNNB1) is a key effector of the canonical Wnt signaling cascade and a structural component of the cadherin-based cell adhesion complex at the plasma membrane. This unconjugated polyclonal reagent from Antibodies.com is raised in rabbit as a purified IgG preparation and supplied at 100 µl, intended for researchers investigating Wnt-driven transcriptional programs, E-cadherin-mediated adhesion, and oncogenic signaling in solid tumor models.

Validated for western blot, immunohistochemistry, and immunofluorescence workflows, the antibody reacts with human, mouse, and rat samples, supporting studies of colorectal and hepatocellular carcinoma lines, intestinal crypt stem cell populations, and embryonic patterning models where nuclear β-catenin accumulation is used as a pathway activation readout. Researchers commonly pair it with phospho-specific Wnt co-receptor antibodies to distinguish ligand-dependent versus mutationally stabilized signaling states.

For handling, aliquot the vial upon arrival, store refrigerated, and protect from repeated freeze-thaw cycles to maintain binding activity over multi-month use. The product is supplied as an unconjugated IgG, allowing downstream conjugation to fluorophores, HRP, or biotin according to the experimental design. For research use only.