Anti-CTBP1 Antibody

The Antibodies.com polyclonal antibody targets C-terminal binding protein 1 (CTBP1), a transcriptional co-repressor and NAD+/NADH-regulated dehydrogenase that interfaces with Wnt/β-catenin, Notch, and Hedgehog signaling pathways. Raised in rabbit and supplied as an unconjugated 100 µl aliquot, this reagent is validated for western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation workflows, supporting studies of epigenetic regulation, metabolic sensing, and tumor suppressor biology. Cross-reactivity has been confirmed against human, mouse, and rat samples, enabling comparative work across standard cell culture and in vivo model systems. The polyclonal format presents multiple epitopes across the CTBP1 sequence, which is advantageous for chromatin immunoprecipitation assays where cross-linked protein complexes can mask individual recognition sites. Researchers investigating EMT, apoptosis, or developmental gene silencing programs can apply this reagent to map CTBP1 occupancy at promoters and enhancers, to assess expression changes in tumor versus matched normal tissue, and to interrogate interaction partners through co-immunoprecipitation. For storage, keep the vial refrigerated at 2 to 8 °C; aliquoting preserves activity across repeated freeze-thaw cycles for long-term projects.