Anti-CSTB Antibody

Cystatin B (CSTB) is a small intracellular cysteine protease inhibitor with roles in lysosomal cathepsin regulation, neuroprotection, and tumor cell behavior. Antibodies.com offers a rabbit polyclonal anti-CSTB reagent supplied unconjugated in a 100 µl vial and validated for western blot and immunohistochemistry on human and mouse specimens.

Researchers investigating Cystatin B use this reagent to study cathepsin regulation in neuronal tissue, examine loss-of-function effects linked to Unverricht-Lundborg disease, and probe expression patterns reported in glioblastoma and certain epithelial carcinomas. Typical workflows include probing endogenous protein abundance in cell lysates by western blot, localizing CSTB in fixed tissue sections by immunohistochemistry, and comparing expression across disease versus control samples.

The polyclonal format increases the chance of recognizing multiple epitopes on the target, which can be useful when working with archival samples where fixation or post-translational modification may mask individual binding sites. The unconjugated formulation gives flexibility to pair the primary with HRP, biotin, or fluorophore-conjugated secondary reagents depending on the detection platform. Aliquot on receipt and store refrigerated; minimize repeated freeze-thaw cycles to preserve binding activity.