Anti-CSK Antibody

This mouse monoclonal IgG2b antibody targets CSK (C-terminal Src kinase), a cytoplasmic tyrosine kinase that phosphorylates the inhibitory C-terminal tyrosine residue of Src-family kinases. Antibodies.com supplies the reagent as a 100 µl unconjugated preparation validated for western blot and immunocytochemistry in human and rat samples, with reactivity demonstrated against the full-length CSK protein.

CSK acts as a key negative regulator of Src-family kinase activity, making this antibody useful for studies of SFK signaling in lymphocyte activation, platelet function, and cytoskeletal remodeling. The unconjugated IgG2b format allows flexible pairing with secondary antibodies for fluorescence or chromogenic detection. Common laboratory use includes probing whole-cell lysates by immunoblotting and visualizing endogenous CSK distribution in fixed cultured cells by immunostaining, with working dilutions determined empirically for each application.

Each vial is shipped refrigerated and should be stored at 4°C for short-term use; for longer-term storage, aliquot and freeze to limit freeze-thaw cycles that can reduce binding activity.