Anti-CSF2RA Antibody

This primary antibody from Antibodies.com targets CSF2RA, the alpha subunit of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor, also designated CD116. Raised in rabbit as a polyclonal reagent, the antibody binds the extracellular portion of the receptor and is supplied unconjugated for flexible detection chemistry.

Validated for western blot (WB) and immunohistochemistry (IHC) workflows, the reagent enables profiling of CSF2RA expression across human myeloid cell populations, including monocytes, neutrophils, eosinophils, and dendritic cells, where GM-CSF signaling drives proliferation, differentiation, and survival. The product is provided in a 100 µl volume, suitable for multiple labeling experiments when stored refrigerated and protected from repeated freeze-thaw cycles.

CSF2RA pairs with CSF2RB to assemble the high-affinity GM-CSF receptor and is implicated in hereditary pulmonary alveolar proteinosis, where receptor mutations disrupt surfactant clearance by alveolar macrophages. Researchers studying cytokine receptor biology, autoimmune inflammation, and pulmonary immune homeostasis rely on this reagent to map CSF2RA distribution in tissue sections and to confirm expression in cell lysates.

Each lot is quality-controlled for human reactivity, with the unconjugated format permitting pairing with horseradish peroxidase, alkaline phosphatase, or fluorophore-labeled secondary antibodies. The polyclonal nature supports detection of multiple epitopes, increasing tolerance for minor sample variation across tissue preparations and cell lines relevant to GM-CSF research.