Anti-Crystallin-αB (S41) Antibody

Crystallin-αB, the ~20 kDa small heat-shock chaperone (HSPB5, CRYAB) encoded by UniProt P02511 (175 amino acids, calculated mass ~20.2 kDa), is targeted at its serine 41 region by this affinity-purified rabbit polyclonal reagent from Antibodies.com. The unconjugated IgG is supplied in a 100 µl vial at 1 mg/ml in phosphate-buffered saline, pH 7.2, with 0.05% sodium azide as preservative, ready for direct incorporation into immunohistochemistry workflows on formalin-fixed, paraffin-embedded tissue. Reactivity has been confirmed in Human, Mouse, and Rat sections, supporting translational studies of cataractogenesis, desmin-related and myofibrillar myopathies, glial stress responses in neural tissue, and stress-induced protein aggregation in cardiac and skeletal muscle. Because the immunogen spans the S41 region of CRYAB, the reagent is suited to probing chaperone regulation at that specific residue on the small heat-shock protein family member. Aliquot upon first thaw to limit freeze-thaw cycles and keep refrigerated in the dark to preserve antigen-binding activity across multiple staining runs.