Anti-CRYAA Antibody

CRYAA (alpha-A crystallin) is a small heat shock protein that acts as a molecular chaperone within the ocular lens, helping preserve transparency and suppress protein aggregation that would otherwise contribute to cataract formation. Mutations in the CRYAA gene have been linked to inherited cataracts and certain retinal disorders, making the protein a recurring focus in ophthalmology, lens development studies, and chaperone biology research. This unconjugated primary antibody from Antibodies.com is a rabbit polyclonal reagent raised against CRYAA, supplied at 100 µl per vial and validated for western blot and immunofluorescence workflows. Reactivity has been established for human, mouse, and rat samples, enabling direct comparison across standard laboratory models without secondary-species mismatches. Investigators working on age-related lens degeneration, stress-response pathways, or the molecular basis of transparency maintenance can use this reagent to probe CRYAA expression and subcellular localization in tissue sections, cultured cells, and prepared lysates. The polyclonal format provides recognition of multiple epitopes on the target, which can be advantageous when studying post-translational modifications or splice variants relevant to lens pathology.