Anti-CRY1 Antibody

This rabbit polyclonal IgG antibody targets human Cryptochrome 1 (CRY1), a core transcriptional repressor of the mammalian circadian clock that interacts with PER proteins to inhibit BMAL1/CLOCK-dependent gene expression in the ~24-hour feedback loop. Produced in rabbit and supplied at 200 µl, the unconjugated reagent is validated for Western blot detection of endogenous CRY1 in human and mouse samples, where the protein is typically observed near the ~66 kDa molecular weight marker in retinal, hepatic, and suprachiasmatic nucleus lysates.

From Antibodies.com, this reagent is supplied as a polyclonal serum and is intended for research use only. It is referenced in studies of sleep phase disorders, FBXL3-mediated proteasomal turnover of clock repressors, and PER/CRY heterodimer assembly in the photolyase/cryptochrome family. The antibody distinguishes CRY1 from the closely related CRY2 paralog, and pairing with peptide-blocking controls is recommended to confirm specificity. Standard handling includes -20°C storage and aliquoting to limit freeze-thaw cycles of the IgG reagent.