Anti-CRKL Antibody

This unconjugated rabbit polyclonal primary antibody from Antibodies.com targets CRKL (CRK-like adaptor protein), a 39 kDa SH2/SH3-domain signaling adaptor involved in BCR-ABL-mediated pathways, integrin signaling, and epithelial-mesenchymal transition. Raised in rabbit and purified by affinity chromatography, the antibody is supplied as 100 µl of liquid stock and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows. It cross-reacts with both human and mouse CRKL, supporting studies in chronic myeloid leukemia (CML) cell line models, kidney development research, and investigations of focal adhesion dynamics. The unconjugated format allows pairing with custom HRP, fluorophore, or biotin labels depending on experimental needs. Researchers commonly use this reagent to probe CRKL phosphorylation status in response to cytokine stimulation, to assess adaptor protein recruitment at the cell membrane, and to examine CRKL expression patterns in normal versus transformed tissue specimens. Store aliquots at -20 °C in single-use working portions to limit freeze-thaw cycles and preserve antibody titer across repeated experiments.