Anti-CRF-RI Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes the type 1 corticotropin-releasing factor receptor (CRF-RI, also known as CRHR1), the principal high-affinity G-protein coupled receptor that mediates corticotropin-releasing factor signaling through the hypothalamic-pituitary-adrenal stress axis. Raised in rabbit and supplied as an unconjugated polyclonal reagent in a 100 µL volume, the antibody is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows and detects the receptor in human, mouse, and rat samples.

CRF-RI is broadly expressed across cortical, hippocampal, cerebellar, hypothalamic, pituitary, and adrenal tissue, supporting research into stress biology, anxiety and depression circuitry, neuroendocrine feedback, and inflammatory modulation of the HPA axis. Because the reagent is unconjugated, laboratories can pair it with their preferred HRP, biotin, or fluorophore-conjugated secondary antibodies for chromogenic western blot and plate-based assays, fluorescent imaging of fixed sections, and chromogenic immunohistochemistry on paraffin or frozen tissue.