Anti-CREB1 (phospho S129) Antibody

This phospho-specific polyclonal reagent from Antibodies.com detects CREB1 when phosphorylated at serine 129, allowing researchers to monitor a kinase-dependent modification on a major cAMP-responsive transcription factor. Raised in rabbit and supplied at 50 µl per vial as an unconjugated IgG preparation, the antibody is validated for western blot detection of the phospho-S129 form in cell and tissue lysates. The S129 site has been described as a substrate for casein kinase family kinases and contributes to regulation of CRE-dependent promoter output, making the reagent useful for studies of cAMP/PKA-linked transcriptional control, neuronal signalling, and chromatin-associated gene regulation. Reactivity is established for the human target, so the antibody can be applied to human cell lines and primary samples, while the polyclonal format gives broad epitope coverage around the modified residue. Researchers working on signal-dependent transcription factors, phosphorylation dynamics, and stress-response pathways will find this a focused tool for tracking the modified protein by immunoblotting.