Anti-CREB1 (phospho S129) Antibody

Raised in rabbit and supplied by antibodies.com as 200 µl of unconjugated polyclonal IgG, this phospho-specific reagent recognizes human CREB1 only when the transcription factor is phosphorylated at serine 129. The epitope maps within the kinase-inducible domain (KID), the region where PKA and related kinases deposit phosphate during cAMP-driven signaling, so the antibody reports pathway activation rather than total CREB1 abundance.

Validated for Western blot, the antibody resolves a discrete band at the expected molecular weight for CREB1 on SDS-PAGE and is widely applied in studies of synaptic plasticity, memory consolidation, and hippocampal long-term potentiation, where Ser129 phosphorylation tracks CREB-dependent transcription. The same readout supports oncology workflows investigating aberrant CREB activity in leukemia, melanoma, and breast cancer models, as well as endocrine and metabolic research linking cAMP signaling to gluconeogenesis and stress responses.

The unconjugated presentation allows researchers to pair the reagent with HRP, fluorescent, or biotinylated secondaries and to run side-by-side lanes with total-CREB1 antibodies for normalization. Host species rabbit, clonality polyclonal, isotype IgG, reactivity human, supplied as a liquid vial for laboratory research use only.