Anti-CREB1 (phospho S129) Antibody

This affinity-purified polyclonal IgG reagent from Antibodies.com selectively recognizes the CREB1 transcription factor when phosphorylated at serine 129, enabling read-out of kinase-driven activation events in the cAMP/PKA signaling cascade. Raised in rabbit and supplied as a 100 µl unconjugated liquid aliquot, the antibody is validated for Western blot analysis of human cell and tissue lysates. The unconjugated format allows pairing with any HRP- or fluorophore-conjugated secondary antibody, supporting flexible chemiluminescent or fluorescence detection workflows in cell biology, neuroscience, and endocrinology laboratories. Phosphorylation-state-specific recognition at the S129 residue allows discrimination between transcriptionally active and basal CREB1 pools across varied stimulation, drug-treatment, or time-course conditions. The reagent is purified by antigen-affinity chromatography against the phospho-S129 epitope and is intended for research use only in signal-transduction studies investigating CREB-dependent gene regulation, neuronal plasticity, and hormone-driven transcriptional responses.