Anti-CREB (Ab-133) Antibody

This rabbit polyclonal reagent from Antibodies.com is raised against the cAMP response element-binding protein (CREB), targeting a region centered on residue 133 that encompasses the functionally important Ser133 phosphorylation site. Produced in rabbit and supplied unconjugated, the antibody is validated for Western blot and immunohistochemistry workflows and cross-reacts with both human and mouse samples, supporting translational studies that compare rodent models with patient-derived tissue.

Each vial provides 100 µL of antiserum suitable for chemiluminescent detection on nitrocellulose membranes and for chromogenic staining of formalin-fixed paraffin-embedded sections. Investigators working on cAMP/PKA signaling, neuronal plasticity, memory consolidation, metabolic regulation, and oncogenic transcription programs routinely use this reagent to monitor CREB abundance alongside downstream targets such as BDNF and c-Fos. For best results, store at -20 °C in single-use aliquots to preserve binding activity across repeated freeze-thaw cycles.