Anti-CREB (Ab-129) Antibody

The polyclonal antibody from Antibodies.com is a rabbit-derived reagent developed for detection of the CREB transcription factor in cellular and tissue samples. CREB (cAMP response element-binding protein) regulates gene expression through cAMP response elements and is widely studied in neuroscience, metabolic research, and cancer biology, where its phosphorylation status influences downstream transcriptional programs.

Supplied as 100 µl of ready-to-use reagent, this unconjugated primary antibody has been validated for Western blot (WB) and immunohistochemistry (IHC) workflows. The antibody recognizes epitopes surrounding residue 129 of human CREB, a region within the kinase-inducible domain of the protein. It cross-reacts with mouse samples, supporting comparative studies between human tissue and rodent model systems. The polyclonal format increases the chance of binding multiple epitopes on the target, which can be advantageous when probing denatured lysates or fixed tissue sections, and the unconjugated format gives researchers flexibility to couple the antibody to their preferred fluorophore or enzyme label.