Anti-CREB-1 Antibody

Raised in rabbits by standard immunization, this polyclonal reagent from Antibodies.com targets CREB-1, a basic leucine zipper (bZIP) transcription factor that binds the cAMP response element (CRE, consensus TGACGTCA) and drives cAMP-responsive gene programs central to neuronal plasticity, learning, memory, and glucose homeostasis. Supplied as 100 µl of unconjugated liquid antibody, the reagent is validated for western blot, immunohistochemistry, and ELISA workflows and has been confirmed reactive with human, mouse, and rat samples.

CREB-1 is phosphorylated at Ser133 by kinases such as PKA, CaMKII/IV, and PKC, an event that recruits CBP/p300 coactivators to activate transcription, and researchers commonly use the antibody to monitor CREB-1 expression and pathway activation in hippocampal neurons, cancer cell lines, and metabolic tissue models. The polyclonal format recognizes multiple epitopes across the full-length CREB-1 protein (UniProt P16220), supporting broad detection in projects where isoform- or phospho-site-specific discrimination is not required. Store refrigerated to preserve antibody activity across longitudinal studies, and aliquot upon receipt to limit freeze-thaw cycles.