Anti-CPSF3L Antibody

The Integrator complex subunit CPSF3L (also referred to as INTS11) carries the endonucleolytic activity responsible for 3' processing of snRNAs, and this polyclonal antibody was raised in rabbit to detect the endogenous protein. Antibodies.com supplies the reagent as 100 µl of unconjugated antiserum at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, a stabilizing buffer that keeps the solution liquid at working bench temperatures. Validated applications include Western blot and immunohistochemistry, with reactivity confirmed against human, mouse, and rat samples, supporting comparative studies of snRNA biogenesis, U1 and U2 processing, and Integrator-dependent regulation of RNA polymerase II transcripts. The vial should be stored at -20°C and protected from light, with freeze-thaw cycles minimized by aliquoting on first use to preserve binding activity through long-term handling.