Anti-CPLX1 Antibody

This rabbit polyclonal primary antibody from Antibodies.com targets CPLX1 (Complexin-1), a small presynaptic SNARE-regulatory protein that modulates synaptic vesicle exocytosis and neurotransmitter release at central nervous system synapses. The unconjugated IgG reagent is validated for Western blot (WB) and immunohistochemistry (IHC) workflows on mouse tissue, making it a useful reagent for neuroscience laboratories studying synaptic transmission, SNARE complex assembly, and presynaptic release mechanisms.

Supplied as a 200 µl liquid aliquot of polyclonal antiserum raised in rabbit, the antibody recognizes the endogenous mouse Complexin-1 protein. Complexin-1 is one of four mammalian complexin isoforms and acts as a clamp-and-facilitator of SNARE-mediated membrane fusion, with functionally distinct roles at inhibitory and excitatory synapse types. Researchers commonly apply anti-CPLX1 reagents to rodent brain lysate to detect the low-molecular-weight Complexin-1 band by Western blot, and to perfusion-fixed mouse brain sections (for example hippocampus, cortex, or cerebellum) to visualize presynaptic terminal localization by IHC.

For best results, refrigerate the antibody in working aliquots, avoid repeated freeze-thaw cycles, and protect the unconjugated format from light during handling. The polyclonal host, mouse reactivity, and dual WB/IHC validation make this a practical choice for studies of synaptic vesicle cycling, active-zone organization, and Complexin-1 expression in knockout and disease-model mouse lines.