Anti-COX7S / A2 Antibody

The COX7S subunit, also referred to as COX7A2, is one of the nuclear-encoded components of cytochrome c oxidase (mitochondrial respiratory chain Complex IV) and contributes to the assembly and stability of the holoenzyme. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against the COX7S target and supplied as 100 µl of ready-to-use antibody, validated for Western blot and immunohistochemistry workflows on human, mouse, and rat samples.

This reagent allows researchers to probe endogenous COX7S protein levels in mitochondrial extracts and tissue sections. The polyclonal format means multiple epitopes are recognized, which can be helpful when signal from a monoclonal reagent is weak. For short-term storage, keep refrigerated at 4°C; aliquoting is recommended to limit repeated freeze-thaw cycles. For IHC applications, antigen retrieval conditions should be optimized to the specific fixation method in use. The unconjugated format lets the end user select their own secondary antibody and detection chemistry, including HRP, biotin, or fluorescence systems depending on the workflow.

In published literature, COX7A2 has been studied in the context of mitochondrial biogenesis, oxidative phosphorylation efficiency, and metabolic adaptation in high-energy-demand tissues. Researchers using this antibody commonly examine Complex IV assembly, mitochondrial responses to physiological or pharmacological challenge, and comparative expression across tissues or species. The reactivity profile covering human, mouse, and rat samples makes this reagent useful in translational studies that bridge animal model and human tissue analysis, including western blot-based expression surveys and immunohistochemistry-based localization studies in fixed specimens.