Anti-COX4I1 Antibody

Cytochrome c oxidase subunit 4 isoform 1 (COX4I1) anchors the catalytic core of mitochondrial complex IV, the terminal oxidase of the electron transport chain. Antibodies.com distributes a rabbit polyclonal antibody raised against this subunit, supplied as 100 µl of unconjugated antiserum and validated for Western blot and immunofluorescence on human specimens.

The protein is embedded in the inner mitochondrial membrane, where it stabilizes the holoenzyme and contributes to proton pumping efficiency. Because expression of COX4I1 is generally maintained across many cell types and treatment conditions, the reagent is widely adopted as a mitochondrial loading control alongside cytosolic reference proteins. Common experimental contexts include studies of oxidative phosphorylation, mitochondrial biogenesis, hypoxia signaling, apoptosis, metabolic reprogramming in cancer, and neurodegeneration.

Aliquot upon receipt and store refrigerated to preserve activity across repeated freeze-thaw cycles; the polyclonal format recognizes multiple epitopes on the target, supporting robust signal in membrane imaging and microscopy of fixed cells.