Anti-COX41 Antibody

COX41 (Cytochrome c oxidase subunit 4 isoform 1, encoded by COX4I1) is a nuclear-encoded component of mitochondrial respiratory chain complex IV. This unconjugated rabbit polyclonal primary antibody, supplied by Antibodies.com, recognizes the human COX4I1 protein and is validated for Western blot and immunohistochemistry applications. The reagent is provided in a 100 µl vial as a polyclonal antiserum, allowing flexible pairing with HRP-, biotin-, or fluorophore-conjugated secondary antibodies for chemiluminescent, chromogenic, or fluorescence detection.

Because COX4I1 is ubiquitously expressed across human tissues and localizes to the inner mitochondrial membrane, this antibody is widely used as a mitochondrial loading control alongside cytoskeletal markers and as a probe for studies of oxidative phosphorylation, mitochondrial biogenesis, and metabolic regulation in research use only workflows. The polyclonal format offers recognition of multiple epitopes on the denatured and native target, supporting reproducible immunoblot signals across varied sample preparations including cultured cell lysates, isolated mitochondrial fractions, and fixed tissue sections for IHC.