Anti-Cox2 Antibody

Cyclooxygenase-2 is the inducible prostaglandin-endoperoxide synthase that drives conversion of arachidonic acid to prostaglandin H2 in inflammatory and oncogenic signaling, and the rabbit polyclonal reagent from Antibodies.com detects this ~69 kDa membrane-associated target in human, mouse, and rat samples. Supplied unconjugated in a 100 µl vial, the antibody is validated for Western blot, immunohistochemistry, and immunofluorescence workflows, and its unconjugated format lets each laboratory conjugate the reagent to HRP, biotin, Alexa Fluor, or other reporters as the experiment requires. Polyclonal recognition of multiple Cox2 epitopes supports detection of inducible isoforms and post-translationally modified species that arise in NF-κB–driven contexts such as colorectal tumors, rheumatoid synovial tissue, neurodegenerative lesions, and atherosclerotic plaques, where the inducible Cox2 signal is routinely contrasted against constitutive Cox1. For best results, the vial should be stored frozen in small working aliquots to limit freeze-thaw loss and preserve binding titer across repeated immunostaining or blotting runs.