Anti-Cox1 Antibody

COX-1 (cyclooxygenase-1, encoded by PTGS1) is the constitutive prostaglandin-endoperoxide synthase that converts arachidonic acid into prostaglandin H2 in many tissues. This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied in a 100 µl vial and targets the human Cox1 protein. It is validated for Western blot and immunohistochemistry workflows, giving laboratories a versatile tool for probing constitutive prostaglandin biosynthesis in tissues such as gastric mucosa, kidney, vascular endothelium, and platelets.

Common applications include comparing constitutive COX-1 expression against inducible COX-2 in inflammation models, examining platelet eicosanoid synthesis pathways, and localizing the enzyme in fixed tissue sections. With a rabbit host, downstream signal detection can be carried out using standard anti-rabbit HRP or fluorescent secondaries, and the unconjugated format allows end-users to couple the antibody to their preferred reporter system as experimental design requires.

Storage recommendations call to refrigerate the working stock, with aliquoting to minimize freeze-thaw exposure, and to protect from light once the antibody is conjugated downstream. For research use only.