Anti-CORO1C Antibody

The Antibodies.com polyclonal antibody reagent specifically recognizes human Coronin 1C (CORO1C), a WD40-repeat, actin-binding protein of the coronin family that concentrates at the leading edge of migrating cells and coordinates actin cytoskeleton remodeling during lamellipodia protrusion, vesicle trafficking, and directed cell motility. Raised in rabbit and supplied as an unconjugated polyclonal, this 100 µl aliquot is validated for western blot and immunohistochemistry workflows and is reactive with human samples.

CORO1C participates in receptor-mediated endocytosis and has been linked to invasive behavior in several solid tumor models, including breast carcinoma and melanoma, where altered expression correlates with cytoskeletal rearrangements that drive migration. Researchers investigating cytoskeletal regulation, host-pathogen interactions, or tumor cell invasion use anti-CORO1C reagents to probe endogenous protein levels, subcellular localization, and post-translational regulation in fixed or lysed preparations.

For long-term storage, keep the vial at -20 °C in working aliquots to limit freeze-thaw cycling, and allow it to equilibrate on ice before dilution into blocking or incubation buffer. Standard dilution ranges apply for the indicated applications; titrate against your specific lysate or tissue section to determine optimal signal-to-background. Full lot-specific validation data and technical documentation are available through Antibodies.com.